The following pdf gives the reaction energy of benzoyl peroxide as 3. Firstaid measures first aid measures eye contact flush with plenty of water. Benzoyl peroxide is commonly found as a white granular tasteless and odorless flammable solid that is used as a bleaching agent for flour, fats, waxes, and oils, as a polymerization catalyst, and in pharmaceuticals. For example, an aqueous solution of hydrogen peroxide containing 30 percent.
Identification of the substancemixture and of the companyundertaking 1. Fisher scientific 1 reagent lane fair lawn, nj 07410. It is important that you familiarize yourself with this chemical and take steps to avoid. Ethers and peroxide forming compounds western sydney university. Benzoyl peroxide bpo or bzo 2 is a medication and industrial chemical. Clean the skin thoroughly before applying this product. The maximum amount used as a flour bleaching agent is 50 mgkg. It may be instructive to follow a typical initiation pathway with benzoyl peroxide for the polymerization of styrene. Environmental precautions for large spills, take precautions to prevent entry into waterways, sewers, or surface drainage. Luperox a98 is available in north america only for delivery by truck freight. Widely available over the counter otc, they both help. Page 16 safety data sheet according to 19072006ec, article 31 printing date 06. Benzoyl peroxide can also be found as a paste that is nonshock sensitive, more difficult to ignite and is generally nonseparating. Ac211780000, ac211780010, ac211780050, ac211780100, ac21178, b2741lb synonyms.
Get special training to wash contaminated clothing. The hydrogen and oxygen atoms within the hydrogen peroxide molecule are covalently. Benzoyl peroxide paste component of 18350, gma kit. Duac topical gel clindamycin 1% benzoyl peroxide 1% 5% 3634 approvedrevised 02aug2011 material sds number version 4 6.
A drug master file dmf is continuously maintained with the united states food and drug administration, and the product complies with usp and pheur monograph specifications. Follow good hygiene procedures when handling chemical materials. Accidental release measures personal precautions wear protective clothing and equipment consistent with the degree of hazard. The former lowers skin ph, the latter disrupts microbial cell membranes. Hazard identification emergency overview appearance.
Wash hands carefully before eating, smoking, drinking. Bp caused mutations in human somatic kidney cells rtecs, 1996. Follow appendix a safe storage and testing guidelines. Benzoyl peroxide has a long history of use in the food industry as a bleaching agent added for flour, whey, and milk for cheese making. Overexposure to this material has been suggested as a cause of the following effects in laboratory animals.
If a precipitate or crystals are present in a peroxideforming chemical do not open the. No exposure limits exist for the constituents of this product. Bp caused unscheduled dna synthesis in rat liver cells rtecs, 1996. Tnt has a explosive energy of slightly above caloriesgram, say 4. These chemicals must be stabilized or decontaminated and discarded within 3 months of opening. Here, we dish on everything you need to know about this acnefighting, glowgiving skincare. Celluloid, in block, rods, rolls, sheets, tubes, etc. Benzoyl peroxide has also been used to treat leg ulcers10,11 and was shown to be of some benefit in patients with seborrhoeic.
Benzoyl peroxide 94360 2023276 45 50 plasticizer, nonphthalate proprietary proprietary 25 30. Benzoyl peroxide decomposes to two benzoyloxy radicals with the rate constant k d 10. Salicylic acid and benzoyl peroxide are two of the most wellknown acnefighting ingredients. Material safety data sheet finished product section 1.
Benzoyl peroxide 94360 proprietary if chemical namecas no is proprietary andor weight% is listed as a range, the specific chemical identity andor percentage of composition has been withheld as a trade secret. Polymerization of vinyl acetate with benzoyl peroxide in ethyl acetate accelerated out of control, resulting in discharge of a large volume of vapor which ignited and exploded. As a medication, it is used to treat mild to moderate acne. Example peroxide forming chemicals table 1 severe peroxide hazard chemicals that can spontaneously decompose, becoming explosive after exposure to air without concentration. Certain features of will be unavailable due to maintenance from saturday morning, april 25th at 9.
Bp was not mutagenic in the ames salmonella microsome test, nor did it cause mutations in yeast. Benzoyl peroxide octadecanoic acid, ester with 1,2,3propanetriol polyethylene glycol crystalline silica tetradecanoic acid, 1methylethyl ester 57556 21645512. When used as an active drug ingredient, the established name i. Prolonged or repeated skin contact with benzoyl peroxide may result in allergic reactions such as sensitisation dermatitis. Always consult the manufacturers safety data sheet.
Cornell university, peroxideforming chemicals, retrieved april 2008. Identification of the substancemixture and of the companyundertaking. Butadiene liquid monomer isopropyl ether sodium amide sodamide. Benzoyl peroxide, hydrous benzoylis peroxidum cum aqua. First aid measures space first aid procedures eye contact space remove contact lenses if present. Benzoyl peroxide is a peroxide with antibacterial, irritant, keratolytic, comedolytic, and antiinflammatory activity.
First aid measures general advice consult a physician. Sigmaaldrich material safety data sheet date printed. Prepare a solution in methanol to contain 10 mg of benzoyl peroxide per ml. Safety data sheet according to 29cfr19101200 and ghs rev. Dibenzoyl peroxide benzoyl peroxide 5 engineering controls. Apply 5 l of this solution and 5 l of a freshly prepared standard solution of hydrous benzoyl peroxide, previously subjected to the assay, in methanol containing 10 mg per ml on a line parallel to and about 2. Please refer to the material safety data sheet for. Benzoyl peroxide propylene glycol isopropyl myristate 21645512 2789 31566311 94360 57556 110270 2. Benzoyl peroxide 25% with water material safety data.
It was prepared by treating benzoyl chloride with barium peroxide, a reaction that probably follows this equation. Show this safety data sheet to the doctor in attendance. Do not eat, smoke, or drink in areas where chemicals are being handled, processed or stored. Benzoyl peroxide was the first organic peroxide prepared by intentional synthesis. Upon topical application, benzoyl peroxide decomposes to release oxygen which is lethal to the bacteria proprionibacterium acnes. Also avoid using benzoyl peroxide and sulfur topical on wounds or on areas of eczema. Benzoyl peroxide is usually prepared by treating hydrogen peroxide with benzoyl chloride.
General room ventilation might be required to maintain operator. A novel approach for incorporating benzoyl peroxide in two. Luperox a75fp pharmaceutical grade benzoyl peroxide is available for shipment anywhere worldwide. Sigmaaldrich 3050 spruce street saint louis mo 63103 usa telephone. Hydrogen peroxide fungicides are typically formulated as. Luperox a75 benzoyl peroxide is a 75% active grade of bpo with remainder water added for added safety, forming a waterwet powder. Benzoyl peroxide sulfur topical side effects, dosage.
Repeated or prolonged contact may cause skin sensitization. Osha pel and acgjh twa are 5 mgm3 for benzoyi peroxide. Benzoyl peroxide has broadspectrum antimicrobial activity that persists for 48 h even when conditions for bacterial growth are optimal. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Benzoyl peroxide kills bacteria and is available by prescription and over the counter. Find msds or sds, a coa, data sheets and more information. Material safety data sheet express composites, inc. Benzoyl peroxide, damped with 25% water article number. Benzoyl peroxide 94360 60 nd nd no no no dibutyl phthalate dbp 84742 10 5 5 no no no water 7732185 balance ne ne no no no section 3. Polymerization of vinyl acetate with benzoyl peroxide in ethyl acetate accelerated out of control, resulting in discharge of a. In the united states, benzoyl peroxide may be used as an active ingredient in otc drug products. The role of benzoyl peroxide in the management of acne.
Benzoyl peroxide msds material safety data sheet or sds, coa and coq, dossiers. One to three times daily, wet skin and cover the entire affected area with a thin layer, liberally applying to areas to be cleansed. Benzoyl peroxide is also known as dibenzoyl peroxide, benzoyl superoxide, debroxide, panoxyl, lucidol, and many other names. Traditional uses like general purpose, highimpact, or expandable polystrenes depend on benzoyl peroxide for bulk polymerizations. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. For more severe cases, it may be used with other treatments. Evidence for the comedolytic effect comes from several studies. Hydrous benzoyl peroxide usp msds quality excipients. Some versions are sold mixed with antibiotics such as clindamycin. Luperox a75fp pharmaceutical grade benzoyl peroxide. Work with experimentally induced comedones by oh and myung25 and kaidbey and kligman26 both demonstrated that 5 per cent benzoyl peroxide was an effective comedolytic. Benzoyl peroxide has caused tumorigenic effects in laboratory animals.
Hydrogen peroxide agricultural marketing service usda. Patient information sheet benzoylperoxide b007 your patch testing results indicate that you have a contact allergy to benzoylperoxide. If it does get into any of these areas, rinse with water. Ddf benzoyl peroxide gel page 1 of 5 material safety data sheet finished product section 1 chemical substanceproduct and company identification finished product name. Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. Mode of action of benzoyl peroxide benzoyl peroxide has both comedolytic and antibacterial effects. Spilled material not immediately cleaned up may increase the fire hazard due to evaporation of water away from the benzoyl peroxide. Chemical product and company identification material identity product name. Call a physician or poison control center immediately. Huffman, kayla, a novel approach for incorporating benzoyl peroxide in twosolution bone cement 20.
Example peroxide forming chemicals cornell university. Search results for benzoyl peroxide at sigmaaldrich. The role of benzoyl peroxide in the management of acne vulgaris. Product identifier onexton clindamycin phosphate and benzoyl peroxide gel, 1. Aug 19, 2019 ever wonder whats so great about the dermatologistfavorite skincare ingredient benzoyl peroxide. A premix of 32% benzoyl peroxide and 68% cornstarch is used in bleaching flour.
Chemical component osha pel acgih tlvtwa acgih stel benzoyl peroxide 5 mgm3 5 mgm3 no data available appropriate engineering controls. Benzoyl peroxide page 3 of 6 change into clean clothing if clothing becomes contaminated. The pharmacy at cornell health carries a variety of. Benzoyl peroxide has caused tumorigenic effects in laboratory. Benzoyl peroxide is metabolized in the skin predominantly in the upper layers of the epidermis to benzoic acid and free oxygen radicals. Diluted forms of benzoyl peroxide when used as acne and skin bleach treatment results in 12% of these applications showing allergic responses and or sensitisation. Ddf benzoyl peroxide gel 99433255 company identification. Trade name benzoyl peroxide, wet with 25% water stock number.
Benzoyl peroxide paste technical data sheet general name. Overexposure to this material has been known to cause the following effects in lab animals. Luperox a98 anhydrous benzoyl peroxide powder is useful for applications like silicones, hybrid polyurethanes, adhesives, or polystyrenes that require low or zero water content. Benzoyl peroxide caused dna damage in human cells rtecs, 1996. This safety data sheet is written to provide health, safety and environmental information for people. Loosen clothing and place exposed in a comfortable position. Due to its irritant effect, benzoyl peroxide increases turnover rate of epithelial cells, thereby peeling the skin and promoting the resolution of. The chemical properties of benzoyl peroxide concerning transportation. Other uses include bleaching flour, hair bleaching, teeth whitening, and textile bleaching.