Benzoyl peroxide can also be found as a paste that is nonshock sensitive, more difficult to ignite and is generally nonseparating. Benzoyl peroxide has caused tumorigenic effects in laboratory. Sigmaaldrich material safety data sheet date printed. Page 16 safety data sheet according to 19072006ec, article 31 printing date 06. Benzoyl peroxide paste technical data sheet general name. Certain features of will be unavailable due to maintenance from saturday morning, april 25th at 9. Benzoyl peroxide bpo or bzo 2 is a medication and industrial chemical. Please refer to the material safety data sheet for. Fisher scientific 1 reagent lane fair lawn, nj 07410. Overexposure to this material has been suggested as a cause of the following effects in laboratory animals. The role of benzoyl peroxide in the management of acne. Firstaid measures first aid measures eye contact flush with plenty of water. If a precipitate or crystals are present in a peroxideforming chemical do not open the.
When used as an active drug ingredient, the established name i. Diluted forms of benzoyl peroxide when used as acne and skin bleach treatment results in 12% of these applications showing allergic responses and or sensitisation. Benzoyl peroxide octadecanoic acid, ester with 1,2,3propanetriol polyethylene glycol crystalline silica tetradecanoic acid, 1methylethyl ester 57556 21645512. Benzoyl peroxide caused dna damage in human cells rtecs, 1996. Chemical component osha pel acgih tlvtwa acgih stel benzoyl peroxide 5 mgm3 5 mgm3 no data available appropriate engineering controls. Dibenzoyl peroxide benzoyl peroxide 5 engineering controls. Hazard identification emergency overview appearance. Benzoyl peroxide sulfur topical side effects, dosage. Follow good hygiene procedures when handling chemical materials. First aid measures space first aid procedures eye contact space remove contact lenses if present. Ddf benzoyl peroxide gel page 1 of 5 material safety data sheet finished product section 1 chemical substanceproduct and company identification finished product name. The pharmacy at cornell health carries a variety of.
Butadiene liquid monomer isopropyl ether sodium amide sodamide. Chemical product and company identification material identity product name. Ethers and peroxide forming compounds western sydney university. Loosen clothing and place exposed in a comfortable position. Example peroxide forming chemicals cornell university. Hydrogen peroxide fungicides are typically formulated as. Always consult the manufacturers safety data sheet. Benzoyl peroxide is usually prepared by treating hydrogen peroxide with benzoyl chloride. Clean the skin thoroughly before applying this product. The maximum amount used as a flour bleaching agent is 50 mgkg. Traditional uses like general purpose, highimpact, or expandable polystrenes depend on benzoyl peroxide for bulk polymerizations. Luperox a98 anhydrous benzoyl peroxide powder is useful for applications like silicones, hybrid polyurethanes, adhesives, or polystyrenes that require low or zero water content. Get special training to wash contaminated clothing.
Prepare a solution in methanol to contain 10 mg of benzoyl peroxide per ml. Hydrous benzoyl peroxide usp msds quality excipients. One to three times daily, wet skin and cover the entire affected area with a thin layer, liberally applying to areas to be cleansed. Trade name benzoyl peroxide, wet with 25% water stock number. Benzoyl peroxide msds material safety data sheet or sds, coa and coq, dossiers. Benzoyl peroxide 94360 60 nd nd no no no dibutyl phthalate dbp 84742 10 5 5 no no no water 7732185 balance ne ne no no no section 3. Upon topical application, benzoyl peroxide decomposes to release oxygen which is lethal to the bacteria proprionibacterium acnes. Spilled material not immediately cleaned up may increase the fire hazard due to evaporation of water away from the benzoyl peroxide. Benzoyl peroxide decomposes to two benzoyloxy radicals with the rate constant k d 10.
Do not eat, smoke, or drink in areas where chemicals are being handled, processed or stored. Benzoyl peroxide page 3 of 6 change into clean clothing if clothing becomes contaminated. Duac topical gel clindamycin 1% benzoyl peroxide 1% 5% 3634 approvedrevised 02aug2011 material sds number version 4 6. Product identifier onexton clindamycin phosphate and benzoyl peroxide gel, 1. Benzoyl peroxide kills bacteria and is available by prescription and over the counter. Evidence for the comedolytic effect comes from several studies. These chemicals must be stabilized or decontaminated and discarded within 3 months of opening. Due to its irritant effect, benzoyl peroxide increases turnover rate of epithelial cells, thereby peeling the skin and promoting the resolution of. Bp caused mutations in human somatic kidney cells rtecs, 1996. In the united states, benzoyl peroxide may be used as an active ingredient in otc drug products.
Luperox a75fp pharmaceutical grade benzoyl peroxide is available for shipment anywhere worldwide. Search results for benzoyl peroxide at sigmaaldrich. Benzoyl peroxide is a peroxide with antibacterial, irritant, keratolytic, comedolytic, and antiinflammatory activity. A premix of 32% benzoyl peroxide and 68% cornstarch is used in bleaching flour. General room ventilation might be required to maintain operator. Environmental precautions for large spills, take precautions to prevent entry into waterways, sewers, or surface drainage. Celluloid, in block, rods, rolls, sheets, tubes, etc.
Benzoyl peroxide has broadspectrum antimicrobial activity that persists for 48 h even when conditions for bacterial growth are optimal. Mode of action of benzoyl peroxide benzoyl peroxide has both comedolytic and antibacterial effects. Benzoyl peroxide has a long history of use in the food industry as a bleaching agent added for flour, whey, and milk for cheese making. Product and company identification space product name clearasil ultra daily face wash space upc codes refer to section 16 space. First aid measures general advice consult a physician. Benzoyl peroxide is metabolized in the skin predominantly in the upper layers of the epidermis to benzoic acid and free oxygen radicals. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Benzoyl peroxide is also known as dibenzoyl peroxide, benzoyl superoxide, debroxide, panoxyl, lucidol, and many other names. Polymerization of vinyl acetate with benzoyl peroxide in ethyl acetate accelerated out of control, resulting in discharge of a large volume of vapor which ignited and exploded. Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. For more severe cases, it may be used with other treatments.
Material safety data sheet express composites, inc. Benzoyl peroxide propylene glycol isopropyl myristate 21645512 2789 31566311 94360 57556 110270 2. Apply 5 l of this solution and 5 l of a freshly prepared standard solution of hydrous benzoyl peroxide, previously subjected to the assay, in methanol containing 10 mg per ml on a line parallel to and about 2. Benzoyl peroxide, damped with 25% water article number. Cornell university, peroxideforming chemicals, retrieved april 2008. Ddf benzoyl peroxide gel 99433255 company identification. Aug 19, 2019 ever wonder whats so great about the dermatologistfavorite skincare ingredient benzoyl peroxide. Benzoyl peroxide is commonly found as a white granular tasteless and odorless flammable solid that is used as a bleaching agent for flour, fats, waxes, and oils, as a polymerization catalyst, and in pharmaceuticals. No exposure limits exist for the constituents of this product. Benzoyl peroxide 25% with water material safety data. Sigmaaldrich 3050 spruce street saint louis mo 63103 usa telephone. Here, we dish on everything you need to know about this acnefighting, glowgiving skincare. The following pdf gives the reaction energy of benzoyl peroxide as 3. Polymerization of vinyl acetate with benzoyl peroxide in ethyl acetate accelerated out of control, resulting in discharge of a.
Salicylic acid and benzoyl peroxide are two of the most wellknown acnefighting ingredients. Patient information sheet benzoylperoxide b007 your patch testing results indicate that you have a contact allergy to benzoylperoxide. Tnt has a explosive energy of slightly above caloriesgram, say 4. Benzoyl peroxide has caused tumorigenic effects in laboratory animals. Bp was not mutagenic in the ames salmonella microsome test, nor did it cause mutations in yeast. Call a physician or poison control center immediately. Luperox a98 is available in north america only for delivery by truck freight.
Luperox a75fp pharmaceutical grade benzoyl peroxide. Overexposure to this material has been known to cause the following effects in lab animals. Show this safety data sheet to the doctor in attendance. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Follow appendix a safe storage and testing guidelines. Benzoyl peroxide has also been used to treat leg ulcers10,11 and was shown to be of some benefit in patients with seborrhoeic. Identification of the substancemixture and of the companyundertaking. Benzoyl peroxide was the first organic peroxide prepared by intentional synthesis. Benzoyl peroxide 94360 2023276 45 50 plasticizer, nonphthalate proprietary proprietary 25 30. Other uses include bleaching flour, hair bleaching, teeth whitening, and textile bleaching. This safety data sheet is written to provide health, safety and environmental information for people. As a medication, it is used to treat mild to moderate acne. The hydrogen and oxygen atoms within the hydrogen peroxide molecule are covalently. Ac211780000, ac211780010, ac211780050, ac211780100, ac21178, b2741lb synonyms. Safety data sheet according to 29cfr19101200 and ghs rev. The role of benzoyl peroxide in the management of acne vulgaris. It was prepared by treating benzoyl chloride with barium peroxide, a reaction that probably follows this equation.
Bp caused unscheduled dna synthesis in rat liver cells rtecs, 1996. Find msds or sds, a coa, data sheets and more information. Material safety data sheet finished product section 1. The chemical properties of benzoyl peroxide concerning transportation. A drug master file dmf is continuously maintained with the united states food and drug administration, and the product complies with usp and pheur monograph specifications. Work with experimentally induced comedones by oh and myung25 and kaidbey and kligman26 both demonstrated that 5 per cent benzoyl peroxide was an effective comedolytic. Some versions are sold mixed with antibiotics such as clindamycin. Accidental release measures personal precautions wear protective clothing and equipment consistent with the degree of hazard. The former lowers skin ph, the latter disrupts microbial cell membranes. Widely available over the counter otc, they both help. Luperox a75 benzoyl peroxide is a 75% active grade of bpo with remainder water added for added safety, forming a waterwet powder. For example, an aqueous solution of hydrogen peroxide containing 30 percent.
Huffman, kayla, a novel approach for incorporating benzoyl peroxide in twosolution bone cement 20. Osha pel and acgjh twa are 5 mgm3 for benzoyi peroxide. Also avoid using benzoyl peroxide and sulfur topical on wounds or on areas of eczema. Benzoyl peroxide, hydrous benzoylis peroxidum cum aqua. Wash hands carefully before eating, smoking, drinking. Repeated or prolonged contact may cause skin sensitization.
Benzoyl peroxide paste component of 18350, gma kit. A novel approach for incorporating benzoyl peroxide in two. Example peroxide forming chemicals table 1 severe peroxide hazard chemicals that can spontaneously decompose, becoming explosive after exposure to air without concentration. It may be instructive to follow a typical initiation pathway with benzoyl peroxide for the polymerization of styrene. Hydrogen peroxide agricultural marketing service usda. Benzoyl peroxide 94360 proprietary if chemical namecas no is proprietary andor weight% is listed as a range, the specific chemical identity andor percentage of composition has been withheld as a trade secret. It is important that you familiarize yourself with this chemical and take steps to avoid.